CHK1-IN-7

CHK1-IN-7 (Compound 10c) is a potent human CHK1 inhibitor. CHK1-IN-7 shows no single agent effect, potentiates the antiproliferative effect of Gemcitabine HY-17026 in both prostate and breast cancer cell lines. CHK1-IN-7 can be used for the research of cancer[1].

Product Specifications

CAS Number

[838823-31-7]

UNSPSC

12352005

Target

Checkpoint Kinase (Chk)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/chk1-in-7.html

Purity

98.0

Solubility

DMSO : 8 mg/mL (ultrasonic; warming)

Smiles

OC1=CC(O)=CC=C1C2=CC=C(C3=NNC(NC4=CC=C(CNC5CC5)C=C4)=C3)C=C2

Molecular Formula

C25H24N4O2

Molecular Weight

412.48

References & Citations

[1]Teng M, et al. Structure-based design and synthesis of (5-arylamino-2H-pyrazol-3-yl) -biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J Med Chem. 2007 Nov 1;50 (22) :5253-6.