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NSC 109555 (ditosylate)

NSC 109555 ditosylate is a potent, selective, ATP-competitive checkpoint kinase 2 (Chk2) inhibitor with an IC50 of 240 nM. NSC 109555 ditosylate can be used for the research of cancer[1].

Product Specifications

CAS Number

66748-43-4

UNSPSC

12352005

Target

Checkpoint Kinase (Chk)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nsc-109555-ditosylate.html

Solubility

10 mM in DMSO

Smiles

O=S(O)(C1=CC=C(C)C=C1)=O.N=C(N)N/N=C(C2=CC=C(NC(NC3=CC=C(/C(C)=N/NC(N)=N)C=C3)=O)C=C2)\C.O=S(O)(C4=CC=C(C)C=C4)=O

Molecular Formula

C33H40N10O7S2

Molecular Weight

752.86

References & Citations

[1]Lountos GT, et al. Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor. Protein Sci. 2009 Jan;18 (1) :92-100.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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