NSC 109555 (ditosylate)
NSC 109555 ditosylate is a potent, selective, ATP-competitive checkpoint kinase 2 (Chk2) inhibitor with an IC50 of 240 nM. NSC 109555 ditosylate can be used for the research of cancer[1].
Product Specifications
CAS Number
66748-43-4
UNSPSC
12352005
Target
Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc-109555-ditosylate.html
Solubility
10 mM in DMSO
Smiles
O=S(O)(C1=CC=C(C)C=C1)=O.N=C(N)N/N=C(C2=CC=C(NC(NC3=CC=C(/C(C)=N/NC(N)=N)C=C3)=O)C=C2)\C.O=S(O)(C4=CC=C(C)C=C4)=O
Molecular Formula
C33H40N10O7S2
Molecular Weight
752.86
References & Citations
[1]Lountos GT, et al. Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor. Protein Sci. 2009 Jan;18 (1) :92-100.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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