Cis-J-113863
Cis-J-113863 is a competitive chemokine receptor 1 (CCR1) antagonist, with IC50 values of 0.9 and 5.8 nM for human and mouse CCR1 receptors, respectively[1].
Product Specifications
CAS Number
[202796-41-6]
Product Name Alternative
UCB35625
UNSPSC
12352005
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cis-j-113863.html
Solubility
10 mM in DMSO
Smiles
CC[N@@+]1(C/C2=C/CCCCCC2)CC[C@H](NC(C3C4=C(OC5=C3C=C(Cl)C=C5)C=CC(Cl)=C4)=O)CC1.[I-]
Molecular Formula
C30H37Cl2IN2O2
Molecular Weight
655.44
References & Citations
[1]M Amat, et al. Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo. Br J Pharmacol. 2006 Nov;149 (6) :666-75.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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