Cis-J-113863

Cis-J-113863 is a competitive chemokine receptor 1 (CCR1) antagonist, with IC50 values of 0.9 and 5.8 nM for human and mouse CCR1 receptors, respectively[1].

Product Specifications

CAS Number

[202796-41-6]

Product Name Alternative

UCB35625

UNSPSC

12352005

Target

CCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cis-j-113863.html

Solubility

10 mM in DMSO

Smiles

CC[N@@+]1(C/C2=C/CCCCCC2)CC[C@H](NC(C3C4=C(OC5=C3C=C(Cl)C=C5)C=CC(Cl)=C4)=O)CC1.[I-]

Molecular Formula

C30H37Cl2IN2O2

Molecular Weight

655.44

References & Citations

[1]M Amat, et al. Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo. Br J Pharmacol. 2006 Nov;149 (6) :666-75.