M50054
M50054 is a potent inhibitor of apoptosis. M50054 inhibits Etoposide-induced caspase-3 activation of U937 cells with an IC50 of 79 μg/mL. M50054 does not directly inhibit the enzymatic activity of caspase-3. M50054 can be used for the research anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia[1].
Product Specifications
CAS Number
54135-60-3
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/m50054.html
Purity
98.44
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C(CC(C(CCC2)=O)C2=O)C(CCC1)=O
Molecular Formula
C13H16O4
Molecular Weight
236.26
Precautions
H302, H315, H319, H335
References & Citations
[1]T Tsuda, et al. Inhibitory effect of M50054, a novel inhibitor of apoptosis, on anti-Fas-antibody-induced hepatitis and chemotherapy-induced alopecia. Eur J Pharmacol.2001 Dec 14;433 (1) :37-45.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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