NIDA-41020

NIDA-41020 is a potent and selective cannabinoid receptor 1 (CB1) antagonist with a Ki of 4.1 nM. NIDA-41020 was designed as a potential radioligand for use in positron emission tomography (PET) [1].

Product Specifications

CAS Number

[502486-89-7]

UNSPSC

12352005

Hazard Statement

H300-H315-H319-H335

Target

Cannabinoid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nida-41020.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NN(C(C2=CC=C(OC)C=C2)=C1C)C3=CC=C(C=C3Cl)Cl)NN4CCCCC4

Molecular Formula

C23H24Cl2N4O2

Molecular Weight

459.37

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Katoch-Rouse R, et al. Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity. J Med Chem. 2003 Feb 13;46 (4) :642-5.