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(Z) -Semaxanib

(Z) -Semaxanib (compound (z) -1) is a potent tyrosine kinase inhibitor. (Z) -Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC50s of 6.28 µM and 8.17 µM, respectively[1].

Product Specifications

CAS Number

194413-58-6

Product Name Alternative

(Z) -SU5416

UNSPSC

12352005

Hazard Statement

H317, H319

Target

C-Met/HGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/z-semaxanib.html

Purity

99.72

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(NC1=C/2C=CC=C1)C2=C/C3=C(C)C=C(C)N3

Molecular Formula

C15H14N2O

Molecular Weight

238.29

Precautions

H317, H319

References & Citations

[1]Ngai MH, So CL, Sullivan MB, Ho HK, Chai CL. Photoinduced Isomerization and Hepatoxicities of Semaxanib, Sunitinib and Related 3-Substituted Indolin-2-ones. ChemMedChem. 2016 Jan 5;11 (1) :72-80.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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