(Z) -Semaxanib
(Z) -Semaxanib (compound (z) -1) is a potent tyrosine kinase inhibitor. (Z) -Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC50s of 6.28 µM and 8.17 µM, respectively[1].
Product Specifications
CAS Number
194413-58-6
Product Name Alternative
(Z) -SU5416
UNSPSC
12352005
Hazard Statement
H317, H319
Target
C-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z-semaxanib.html
Purity
99.72
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=C/2C=CC=C1)C2=C/C3=C(C)C=C(C)N3
Molecular Formula
C15H14N2O
Molecular Weight
238.29
Precautions
H317, H319
References & Citations
[1]Ngai MH, So CL, Sullivan MB, Ho HK, Chai CL. Photoinduced Isomerization and Hepatoxicities of Semaxanib, Sunitinib and Related 3-Substituted Indolin-2-ones. ChemMedChem. 2016 Jan 5;11 (1) :72-80.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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