NAADP

NAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling[1][2].

Product Specifications

CAS Number

5502-96-5

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/naadp.html

Purity

95.8

Solubility

H2O : 50 mg/mL (ultrasonic; warming)

Smiles

NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP(OP(OC[C@H]4O[C@@H]([N+]5=CC(C(O)=O)=CC=C5)[C@H](O)[C@@H]4O)(O)=O)(O)=O)[C@@H](O)[C@H]3OP(O)([O-])=O

Molecular Formula

C21H27N6O18P3

Molecular Weight

744.39

Precautions

H315, H319, H335

References & Citations

[1]Walseth TF, et al: From Discovery to Mechanism. Front Immunol. 2021 Sep 7;12:703326. |[2]Davis LC, et al. NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing. Curr Biol. 2012 Dec 18;22 (24) :2331-7. |[3]Rah SY, et al. NAADP-mediated Ca2+ signaling promotes autophagy and protects against LPS-induced liver injury. FASEB J. 2017 Jul;31 (7) :3126-3137.