Xestospongin C

Xestospongin C ((-) -Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca2+ release from cerebellar microsomes with an IC50 of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca2+ signaling in neuronal and nonneuronal cells[1][2][3].

Product Specifications

CAS Number

[88903-69-9]

Product Name Alternative

(-) -Xestospongin C

UNSPSC

12352005

Target

Apoptosis; Calcium Channel

Type

Natural Products

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/xestospongin-c.html

Purity

99.9

Solubility

DMSO : 4.47 mg/mL (ultrasonic; warming)

Smiles

[H][C@]1([C@](CCCCCC[C@@](CCN2CCC3)([H])O[C@@]2([H])[C@]3([H])CCCCCC4)([H])CCC5)N5CC[C@]4([H])O1

Molecular Formula

C28H50N2O2

Molecular Weight

446.71

References & Citations

[1]Wang ZJ, et al. Xestospongin C, a Reversible IP3 Receptor Antagonist, Alleviates the Cognitive and Pathological Impairments in APP/PS1 Mice of Alzheimer's Disease. J Alzheimers Dis. 2019;72 (4) :1217-1231.|[2]Gafni J, Munsch JA, Lam TH, Catlin MC, Costa LG, Molinski TF, Pessah IN. Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. Neuron. 1997 Sep;19 (3) :723-33. doi: 10.1016/s0896-6273 (00) 80384-0. PMID: 9331361.|[3]Castonguay A, et al. Xestospongin C is a potent inhibitor of SERCA at a vertebrate synapse. Cell Calcium. 2002;32 (1) :39-47.