SB 268262

CGRP antagonist 4 is an antagonist of calcitonin gene-related peptide (CGRP) receptor. CGRP antagonist 4 shows the highest affinity for CGRP receptors in the human brain. CGRP antagonist 4 can be used to study the binding properties of non-peptide calcitonin gene-related peptide (CGRP) receptor antagonist (gepants) in rat, pig and human menes [1].

Product Specifications

CAS Number

[217438-17-0]

UNSPSC

12352005

Hazard Statement

H302, H319

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cgrp-antagonist-4.html

Purity

99.9

Solubility

10 mM in DMSO

Smiles

O=C(N(C)C1=CC=CC=C1C)C2=CC=C(S(C3=NC=CS3)=O)C([N+]([O-])=O)=C2

Molecular Formula

C18H15N3O4S2

Molecular Weight

401.46

Precautions

H302, H319

References & Citations

[1]Warfvinge K, et al. The Presence of Calcitonin Gene-Related Peptide and Its Receptors in Rat, Pig and Human Brain: Species Differences in Calcitonin Gene-Related Peptide Pharmacology. Pharmacology. 2019;104 (5-6) :332-341.