(Rac) -AZD3839

(Rac) -AZD3839 is an orally active beta-amyloid precursor protein cleaving enzyme (BACE1) inhibitor that is blood-brain barrier-permeable. (Rac) -AZD3839 has an affinity for the human ether-a-go-go related gene (hERG) ion channel. (Rac) -AZD3839 can be used in the research of Alzheimer's disease[1].

Product Specifications

CAS Number

[1227163-56-5]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rac-azd3839.html

Solubility

10 mM in DMSO

Smiles

NC1=NC(C2=CC(C(F)(F)F)=NC=C2)(C3=CC=CC(C4=CN=CN=C4)=C3)C5=C1C(F)=CC=C5

Molecular Formula

C24H15F4N5

Molecular Weight

449.40

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Britt-Marie Swahn, et, al. Design and synthesis of β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of β-amyloid peptides. J Med Chem 2012, 55, 21.