TC-A 2317 (hydrochloride)

TC-A 2317 hydrochloride is an orally active Aurora A kinase inhibitor (Ki=1.2 nM) . TC-A 2317 hydrochloride exhibits excellent selectivity to Aurora B kinase (Ki=101 nM) and other 60 kinases, good cell permeability and good PK profile. Antitumor activity[1].

Product Specifications

CAS Number

[1245907-03-2]

UNSPSC

12352005

Target

Aurora Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tc-a-2317-hydrochloride.html

Purity

99.57

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1=C(C)C=C(NC2=NNC(C)=C2)N=C1NC(C)CCCC(C)(O)C.[H]Cl

Molecular Formula

C19H29ClN6O

Molecular Weight

392.93

References & Citations

[1]Ando R, et al. 3-Cyano-6- (5-methyl-3-pyrazoloamino) pyridines: selective Aurora A kinase inhibitors. Bioorg Med Chem Lett. 2010;20 (15) :4709-4711.