TC-A 2317 (hydrochloride)
TC-A 2317 hydrochloride is an orally active Aurora A kinase inhibitor (Ki=1.2 nM) . TC-A 2317 hydrochloride exhibits excellent selectivity to Aurora B kinase (Ki=101 nM) and other 60 kinases, good cell permeability and good PK profile. Antitumor activity[1].
Product Specifications
CAS Number
1245907-03-2
UNSPSC
12352005
Target
Aurora Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tc-a-2317-hydrochloride.html
Purity
99.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=C(C)C=C(NC2=NNC(C)=C2)N=C1NC(C)CCCC(C)(O)C.[H]Cl
Molecular Formula
C19H29ClN6O
Molecular Weight
392.93
References & Citations
[1]Ando R, et al. 3-Cyano-6- (5-methyl-3-pyrazoloamino) pyridines: selective Aurora A kinase inhibitors. Bioorg Med Chem Lett. 2010;20 (15) :4709-4711.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A; Aurora B
Available Sizes
Frequently Asked Questions
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