PF-945863
PF-945863 is an orally active macrolide antibiotic that can be used for the research of multidrug resistant respiratory tract bacterial strains[1][2].
Product Specifications
CAS Number
893556-85-9
UNSPSC
12352005
Target
Antibiotic
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pf-945863.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2CN([C@@H](C3=CC=NC4=C3C=CC=N4)C)C2)[C@@]([C@H]5C)([H])[C@@](C)([C@H](OC([C@@H](C([C@H](C)[C@@H](O[C@@]6([H])[C@@H]([C@H](C[C@@H](C)O6)N(C)C)O)[C@@](OC)(C)C[C@@H](C)C5=O)=O)C)=O)CC)O1
Molecular Formula
C44H65N5O10
Molecular Weight
824.01
References & Citations
[1]Zientek M, et al. In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. Drug Metab Dispos. 2010;38 (8) :1322-1327.|[2]Magee TV, et al. Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. J Med Chem. 2009;52 (23) :7446-7457.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Macrolide
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