GYKI 52466 (hydrochloride)
Product Specifications
UNSPSC Description
GYKI 52466 hydrochloride is an orally active, highly selective and noncompetitive AMPA/kainate receptor antagonist with the IC50 values of 7.5 and 11μM, respectively. GYKI 52466 hydrochloride has good blood brain barrier permeability and anticonvulsant effect. GYKI 52466 hydrochloride can be used in Parkinson's disease research[1][2].
Target Antigen
iGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gyki-52466-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
NC1=CC=C(C2=NN=C(C)CC3=CC4=C(OCO4)C=C32)C=C1.[H]Cl
Molecular Weight
329.78
References & Citations
[1]S D Donevan, et al. GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses. Neuron. 1993 Jan;10(1):51-9.|[2]A G Chapman, et al. The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice. Epilepsy Res. 1991 Jul;9(2):92-6.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103234B/GYKI-52466-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103234B/
Clinical Information
No Development Reported
CAS Number
192065-56-8
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6290587-01 0.2 mL
CYTH1, NT (CYTH1, D17S811E, PSCD1, Cytohesin-1, PH, SEC7 and coiled-coil domain-containing protein 1, SEC7 homolog B2-1) (FITC)
Ask
View Details 
MBS6290587-02 5x 0.2 mL
CYTH1, NT (CYTH1, D17S811E, PSCD1, Cytohesin-1, PH, SEC7 and coiled-coil domain-containing protein 1, SEC7 homolog B2-1) (FITC)
Ask
View Details 