Azepexole (dihydrochloride)

Azepexole (B-HT 933) dihydrochloride is a potent and selective alpha 2-adrenoceptor agonist with pKis of 8.3, 7.6, and 7.5 for α2A-, α2B- and α2C-adrenoceptor subtypes, resepctively[1]. Azepexole dihydrochloride causes concentration-dependent inhibition of peristaltic contractions (IC50= 78.72 nM) [2].

Product Specifications

CAS Number

[36067-72-8]

Product Name Alternative

B-HT 933 (dihydrochloride) ; Oxazoloazepin (dihydrochloride)

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/azepexole-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

NC(O1)=NC2=C1CCN(CC)CC2.[H]Cl.[H]Cl

Molecular Formula

C9H17Cl2N3O

Molecular Weight

254.16

References & Citations

[1]Altamirano-Espinoza AH, et al. Specific role of α2A - and α2B -, but not α2C -, adrenoceptor subtypes in the inhibition of the vasopressor sympathetic out-flow in diabetic pithed rats. Basic Clin Pharmacol Toxicol. 2015;117 (1) :31-38.