HEMADO

HEMADO is a potent and selective adenosine A3 receptor agonist with a Ki of 1.1 nM at the human A3 subtype[1]. HEMADO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[403842-38-6]

UNSPSC

12352005

Hazard Statement

H302

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hemado.html

Purity

99.0

Solubility

DMSO : 20 mg/mL (ultrasonic; warming)

Smiles

OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C2N=C(C#CCCCC)N=C3NC)O1)O)O

Molecular Formula

C17H23N5O4

Molecular Weight

361.40

Precautions

H302

References & Citations

[1]Klotz KN, et al. [3H]HEMADO— a novel tritiated agonist selective for the human adenosine A3 receptor. Eur J Pharmacol. 2007 Feb 5;556 (1-3) :14-8. Epub 2006 Oct 27.|[2]Volpini R, et al. N (6) -alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A (3) receptor and a starting point for searching A (2B) ligands. J Med Chem. 2002 Jul 18;45 (15) :3271-9.