CV1808
CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively[1].
Product Specifications
CAS Number
53296-10-9
Product Name Alternative
2-Phenylaminoadenosine
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Adenosine Receptor; Endogenous Metabolite
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cv1808.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=C2C(N([C@@]3([H])[C@@H]([C@@H]([C@H](O3)CO)O)O)C=N2)=NC(NC4=CC=CC=C4)=N1
Molecular Formula
C16H18N6O4
Molecular Weight
358.35
Precautions
H315, H319, H320
References & Citations
[1]K H Yip, et al. Reciprocal modulation of anti-IgE induced histamine release from human mast cells by A₁ and A (2B) adenosine receptors. Br J Pharmacol. 2011 Sep;164 (2b) :807-19. |[2]I van der Ploeg, et al.Functional characterization of adenosine A2 receptors in Jurkat cells and PC12 cells using adenosine receptor agonists. Naunyn Schmiedebergs Arch Pharmacol.1996 Feb;353 (3) :250-60. |[3]Ming-Guo Feng, et al. Afferent arteriolar vasodilator effect of adenosine predominantly involves adenosine A2B receptor activation. Am J Physiol Renal Physiol. 2010 Aug;299 (2) :F310-5.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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