LUF5834
LUF5834 is a selective A2B adenosine receptor (A2BR) partial agonist (EC50 = 12 nM) . LUF5834 is also a partial A1/A2A adenosine receptor agonist (lacking selectivity) with Ki values of 2.6 and 28 nM, respectively[1][2].
Product Specifications
CAS Number
333962-91-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/luf5834.html
Purity
99.8
Solubility
DMSO : 20 mg/mL (ultrasonic; warming)
Smiles
N#CC1=C(C2=CC=C(O)C=C2)C(C#N)=C(SCC3=NC=CN3)N=C1N
Molecular Formula
C17H12N6OS
Molecular Weight
348.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Beukers MW, et al. New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine. J Med Chem. 2004 Jul 15;47 (15) :3707-9. |[2]Lane JR, et al. A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A (2a) receptor. Mol Pharmacol. 2012 Mar;81 (3) :475-87.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR) ; Adenosine A2B receptor (A2BR)
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