LUF5834

LUF5834 is a selective A2B adenosine receptor (A2BR) partial agonist (EC50 = 12 nM) . LUF5834 is also a partial A1/A2A adenosine receptor agonist (lacking selectivity) with Ki values of 2.6 and 28 nM, respectively[1][2].

Product Specifications

CAS Number

[333962-91-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/luf5834.html

Purity

99.8

Solubility

DMSO : 20 mg/mL (ultrasonic; warming)

Smiles

N#CC1=C(C2=CC=C(O)C=C2)C(C#N)=C(SCC3=NC=CN3)N=C1N

Molecular Formula

C17H12N6OS

Molecular Weight

348.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Beukers MW, et al. New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine. J Med Chem. 2004 Jul 15;47 (15) :3707-9. |[2]Lane JR, et al. A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A (2a) receptor. Mol Pharmacol. 2012 Mar;81 (3) :475-87.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Adenosine A1 receptor (A1R) ; Adenosine A2A receptor (A2AR) ; Adenosine A2B receptor (A2BR)

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