1-Deazaadenosine

1-Deazaadenosine is a potent Adenosine deaminase (ADA) inhibitor with a Ki value of 0.66 μM. 1-Deazaadenosine exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders[1][2].

Product Specifications

CAS Number

[14432-09-8]

UNSPSC

12352005

Target

Adenosine Deaminase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-deazaadenosine.html

Purity

98.9

Solubility

10 mM in DMSO

Smiles

NC1=C2C(N([C@H]3[C@@H]([C@@H]([C@@H](CO)O3)O)O)C=N2)=NC=C1

Molecular Formula

C11H14N4O4

Molecular Weight

266.25

References & Citations

[1]Cristalli G, et al.Adenosine deaminase inhibitors: Structure-activity relationships in 1-deazaadenosine and erythro-9- (2-hydroxy-3-nonyl) adenine analogues. Drug Dev.Res.|[2]Cristalli G, et al.Improved synthesis and antitumor activity of 1-deazaadenosine.J Med Chem. 1987 Sep;30 (9) :1686-8.