SB-221284
SB 221284 is a selective 5-HT2C/2B receptor antagonist with pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. SB 221284 can be used for the research of neurological disease[1].
Product Specifications
CAS Number
196965-14-7
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sb-221284.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC2=C1C=C(C(F)(F)F)C(SC)=C2)NC3=CC=CN=C3
Molecular Formula
C16H14F3N3OS
Molecular Weight
353.36
References & Citations
[1]Hutson PH, et al. Activation of mesolimbic dopamine function by phencyclidine is enhanced by 5-HT (2C/2B) receptor antagonists: neurochemical and behavioural studies. Neuropharmacology. 2000;39 (12) :2318-2328.|[2]Bromidge SM, et al. Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1- (3-pyridylcarbamoyl) indolines. J Med Chem. 1998;41 (10) :1598-1612.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; α-1 microglobulin
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