Elarofiban
Elarofiban (RWJ-53308) is a nonpeptide, orally active antagonist for fibrinogen receptor αIIbβ3 (GPIIb/IIIa), with an IC50 of 0.15 nM. Elarofiban has the potential for platelet mediated thrombotic disorders research[1].
Product Specifications
CAS Number
198958-88-2
Product Name Alternative
RWJ-53308
UNSPSC
12352005
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/elarofiban.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H](C1=CN=CC=C1)CC(O)=O)[C@H]2CN(CCC2)C(CCC3CCNCC3)=O
Molecular Formula
C22H32N4O4
Molecular Weight
416.51
References & Citations
[1]Judith H. Cohen, et al. A Practical Synthesis of the Platelet Fibrinogen Antagonist, Elarofiban. Organic Process Research & Development 2003, 7, 866-872.|[2]De Corte BL, et al., Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins. Bioorg Med Chem Lett. 2004 Oct 18;14 (20) :5227-32.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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