SB-216641A

SB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT1B/D receptor. SB-216641A shows high affinity and selectivity for h5-HT1B receptors over h5-HT1D receptors. SB-216641A inhibits the function of SKF-99101H[1][2].

Product Specifications

CAS Number

[193611-67-5]

Product Name Alternative

SB-216641 (hydrochloride)

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sb-216641a.html

Purity

98.0

Solubility

H2O : 26.15 mg/mL (ultrasonic; warming) |DMSO : 5 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(C2=C(C)C=C(C3=NOC(C)=N3)C=C2)C=C1)NC4=CC=C(C(OCCN(C)C)=C4)OC.Cl

Molecular Formula

C28H31ClN4O4

Molecular Weight

523.02

References & Citations

[1]Hagan JJ, et al. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur J Pharmacol. 1997 Jul 23;331 (2-3) :169-74. |[2]De Ponti F, et al. Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists. Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285 (1) :G96-104.