LY215840

LY215840, a 5-HT7 receptor ligand and a 5-HT2 receptor antagonist, blocks serotonin-induced relaxation in canine coronary artery[1][2].

Product Specifications

CAS Number

[137328-52-0]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ly215840.html

Solubility

10 mM in DMSO

Smiles

CC(N1C2=CC=CC3=C2C(C[C@]4([H])[C@]3([H])C[C@@H](C(N[C@@H]5[C@@H](CCC5)O)=O)CN4C)=C1)C

Molecular Formula

C24H33N3O2

Molecular Weight

395.54

References & Citations

[1]D J Cushing, et al. LY215840, a high-affinity 5-HT7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery. J Pharmacol Exp Ther. 1996 Jun;277 (3) :1560-6.|[2]M L Cohen , et al. LY215840, a potent 5-hydroxytryptamine (5-HT) 2 receptor antagonist, blocks vascular and platelet 5-HT2 receptors and delays occlusion in a rabbit model of thrombosis. J Pharmacol Exp Ther. 1992 Apr;261 (1) :202-8.