Mesulergine (hydrochloride)

Mesulergine (CU32-085) hydrochloride is a potent 5-HT2C antagonist and dopamine (DA) agonist. Mesulergine hydrochloride presentes hyperphagia. Mesulergine hydrochloride has the potential for the research of cognitive processes[1][2].

Product Specifications

CAS Number

[72786-12-0]

Product Name Alternative

CU32-085 (hydrochloride)

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mesulergine-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

CN1C2=C3C([C@]4([H])[C@@](N(C[C@H](C4)NS(N(C)C)(=O)=O)C)([H])CC3=C1)=CC=C2.Cl

Molecular Formula

C18H27ClN4O2S

Molecular Weight

398.95

References & Citations

[1]Giannakopoulos G, et al. Effects of mesulergine treatment on diet selection, brain serotonin (5-HT) and dopamine (DA) turnover in free feeding rats. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Jul;22 (5) :803-13. |[2]Khaliq S, et al. Influence of serotonergic 5-HT2C receptor antagonist mesulergine in the reversal of memory deficits induced by mCPP. J Coll Physicians Surg Pak. 2012 Feb;22 (2) :75-9.