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(Rac) -WAY-161503 (hydrochloride)

(Rac) -WAY-161503 hydrochloride is a potent, selective, high affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac) -WAY-161503 hydrochloride displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac) -WAY-161503 hydrochloride has anti-obesity and antidepressant effects[1][2].

Product Specifications

CAS Number

276695-22-8

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rac-way-161503-hydrochloride.html

Purity

99.5

Solubility

10 mM in DMSO

Smiles

O=C1C(CNCC2)N2C3=C(C=C(Cl)C(Cl)=C3)N1.[H]Cl

Molecular Formula

C11H12Cl3N3O

Molecular Weight

308.59

References & Citations

[1]Halberstadt AL, et al. 5-HT (2A) and 5-HT (2C) receptors exert opposing effects on locomotor activity in mice. Neuropsychopharmacology. 2009 Jul;34 (8) :1958-67. |[2]Welmaker GS, et al. Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5- (6H) ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines. Bioorg Med Chem Lett. 2000 Sep 4;10 (17) :1991-4.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT2 Receptor; α-1 microglobulin

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