SB 206553 (hydrochloride)

SB 206553 hydrochloride is a high affinity, selective and orally active 5-HT2B / 5-HT2C receptor antagonist (rat 5-HT2B pA2 = 8.89, human 5-HT2C pKi = 7.92) [1]. SB 206553 possesses anxiolytic-like properties[2].

Product Specifications

CAS Number

[1197334-04-5]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sb-206553-hydrochloride.html

Purity

99.36

Solubility

DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1C(C(CC1)=C2)=CC3=C2N(C)C=C3)NC4=CC=CN=C4.[H]Cl

Molecular Formula

C17H17ClN4O

Molecular Weight

328.80

References & Citations

[1]Forbes IT, et al. 5-Methyl-1- (3-pyridylcarbamoyl) -1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT2C/5-HT2B receptor antagonist with improved affinity, selectivity, and oral activity. J Med Chem. 1995 Jul 7;38 (14) :2524-30. |[2]Kennett GA, et al. In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties. Br J Pharmacol. 1996 Feb;117 (3) :427-434.