PNU109291
PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation[1].
Product Specifications
CAS Number
187665-60-7
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pnu109291.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C2C(CCO[C@H]2CCN3CCN(C4=CC=C(OC)C=C4)CC3)=C1)NC
Molecular Formula
C24H31N3O3
Molecular Weight
409.52
References & Citations
[1]Cutrer FM, et al. Effects of PNU-109,291, a selective 5-HT1D receptor agonist, on electrically induced dural plasma extravasation and capsaicin-evoked c-fos immunoreactivity within trigeminal nucleus caudalis. Neuropharmacology. 1999 Jul;38 (7) :1043-53.|[2]Winters BL, et al. Inflammation induces developmentally regulated sumatriptan inhibition of spinal synaptic transmission. Br J Pharmacol. 2020 Aug;177 (16) :3730-3743.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor
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