SB 258719 (hydrochloride)
SB 258719 hydrochloride is a selective 5-HT7 receptor antagonist displayed high affnity (pKi=7.5) for the receptor. SB-258719 hydrochloride can be used for the research of cancer and neurological diseases[1][2].
Product Specifications
CAS Number
1217674-10-6
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sb-258719-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=CC(C)=C1)(N(C)[C@H](C)CCN2CCC(C)CC2)=O.[H]Cl
Molecular Formula
C18H31ClN2O2S
Molecular Weight
374.97
References & Citations
[1] Thomas DR, et al. Functional characterisation of the human cloned 5-HT7 receptor (long form) ; antagonist profile of SB-258719. Br J Pharmacol. 1998;124 (6) :1300-1306.|[2]Guscott MR, et al. The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor. Neuropharmacology. 2003;44 (8) :1031-1037.|[3]Fatima S, et al. 5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing β-catenin. Mol Oncol. 2016;10 (2) :195-212.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT7 Receptor; MUC3
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