Org37684
Org37684 is a highly potent 5-HT2C receptor agonist (pEC50=8.17) . Org37684 exhibits a rank order of potency of 5-HT2C>5-HT2B>5-HT2A. Its selectivity for the 5-HT2C receptor is approximately 2.5 times over the 5-HT2B (pEC50=7.96) and ten times for the 5-HT2A (pEC50=7.11) receptor[1].
Product Specifications
CAS Number
213007-95-5
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/org37684.html
Solubility
10 mM in DMSO
Smiles
COC1=C(O[C@@H]2CNCC2)C3=C(CCC3)C=C1.[H]Cl
Molecular Formula
C14H20ClNO2
Molecular Weight
269.77
References & Citations
[1]Porter RH, et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br J Pharmacol. 1999;128 (1) :13-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor
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