Pruvanserin (hydrochloride)

Pruvanserin hydrochloride (EMD 281014) is a selective serotonin 5-HT2A receptor antagonist with IC50 values of 0.35 nM and 1 nM for human and rat 5-HT2A receptors. Pruvanserin (hydrochloride) can be used for the research of schizophrenia[1].

Product Specifications

CAS Number

[443144-27-2]

Product Name Alternative

EMD 281014; LY 2422347 (hydrochloride)

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pruvanserin-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

N#CC1=CNC2=C1C=CC=C2C(N3CCN(CC3)CCC4=CC=C(C=C4)F)=O.Cl

Molecular Formula

C22H22ClFN4O

Molecular Weight

412.89

References & Citations

[1]Bartoszyk GD, et al. EMD 281014, a new selective serotonin 5-HT2A receptor antagonist. Eur J Pharmacol. 2003 Jul 25;473 (2-3) :229-30.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

5-HT2 Receptor

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