Pruvanserin (hydrochloride)
Pruvanserin hydrochloride (EMD 281014) is a selective serotonin 5-HT2A receptor antagonist with IC50 values of 0.35 nM and 1 nM for human and rat 5-HT2A receptors. Pruvanserin (hydrochloride) can be used for the research of schizophrenia[1].
Product Specifications
CAS Number
[443144-27-2]
Product Name Alternative
EMD 281014; LY 2422347 (hydrochloride)
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pruvanserin-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CNC2=C1C=CC=C2C(N3CCN(CC3)CCC4=CC=C(C=C4)F)=O.Cl
Molecular Formula
C22H22ClFN4O
Molecular Weight
412.89
References & Citations
[1]Bartoszyk GD, et al. EMD 281014, a new selective serotonin 5-HT2A receptor antagonist. Eur J Pharmacol. 2003 Jul 25;473 (2-3) :229-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT2 Receptor
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