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ST1936 (oxalate)

ST1936 oxalate is a selective, nanomolar affinity 5-HT6 receptor agonist with Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively. ST1936 oxalate also shows moderate affinity (Ki of 300 nM) for human and rat α2 adrenergic receptor[1].

Product Specifications

CAS Number

1782228-83-4

UNSPSC

12352005

Target

5-HT Receptor; Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/st1936-oxalate.html

Solubility

10 mM in DMSO

Smiles

CC(N1)=C(CCN(C)C)C2=C1C=CC(Cl)=C2.O=C(O)C(O)=O

Molecular Formula

C15H19ClN2O4

Molecular Weight

326.78

References & Citations

[1]Borsini F, et al. Effects of ST1936, a selective serotonin-6 agonist, on electrical activity of putative mesencephalic dopaminergic neurons in the rat brain. J Psychopharmacol. 2015 Jul;29 (7) :802-11.|[2]Riccioni T, et al. ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors. Eur J Pharmacol. 2011;661 (1-3) :8-14. |[3]Tassone A, et al. Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission. Neuropharmacology. 2011;61 (4) :632-637. |[4]Valentini V, et al. A microdialysis study of ST1936, a novel 5-HT6 receptor agonist. Neuropharmacology. 2011;60 (4) :602-608.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT2 Receptor;5-HT6 Receptor;5-HT7 Receptor; MUC2; MUC3; α adrenergic receptor; α-1 microglobulin

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