LP 12 (hydrochloride hydrate)
LP 12 hydrochloride hydrate is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 hydrochloride hydrate displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively) [1][2].
Product Specifications
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lp-12-hydrochloride-hydrate.html
Purity
99.0
Solubility
DMSO : 6 mg/mL (ultrasonic; warming)
Smiles
O=C(NC1CCCC2=C1C=CC=C2)CCCCCN3CCN(C4=CC=CC=C4C5=CC=CC=C5)CC3.[H]Cl.[x].O
Molecular Formula
C32H39N3O·HCl·xH2O
References & Citations
[1]Marcello Leopoldo, et al. Structure-activity relationship study on N- (1,2,3,4-tetrahydronaphthalen-1-yl) -4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. J Med Chem. 2007 Aug 23;50 (17) :4214-21.|[2]Sugiyama Y, et, al. Effects of 5-hydroxytryptamine on spermatozoal hyperactivation and in vitro fertilization in mice. J Reprod Dev. 2019 Dec 18;65 (6) :541-550.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor;5-HT2 Receptor;5-HT7 Receptor
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