LP 12 (hydrochloride)

LP 12 hydrochloride (compound 21) is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 hydrochloride displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively) [1][2].

Product Specifications

CAS Number

[1185136-22-4]

UNSPSC

12352005

Hazard Statement

H319

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lp-12-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1CCCC2=C1C=CC=C2)CCCCCN3CCN(C4=CC=CC=C4C5=CC=CC=C5)CC3.[H]Cl

Molecular Formula

C32H40ClN3O

Molecular Weight

518.13

Precautions

P264-P280-P305+P351+P338

References & Citations

[1]Marcello Leopoldo, et al. Structure-activity relationship study on N- (1,2,3,4-tetrahydronaphthalen-1-yl) -4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. J Med Chem. 2007 Aug 23;50 (17) :4214-21. |[2]Sugiyama Y, et, al. Effects of 5-hydroxytryptamine on spermatozoal hyperactivation and in vitro fertilization in mice. J Reprod Dev. 2019 Dec 18;65 (6) :541-550.