CP-135807

CP-135807 is an orally active and selective 5-HT1D agonist (IC50=3.1 nM), bovine) . CP-135807 mediates central psychoactivity and can be used in antidepressant research[1][2].

Product Specifications

CAS Number

[151272-90-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cp-135807.html

Solubility

10 mM in DMSO

Smiles

O=[N+](C1=CC=CN=C1NC2=CC3=C(NC=C3C[C@@H]4N(C)CCC4)C=C2)[O-]

Molecular Formula

C19H21N5O2

Molecular Weight

351.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Mansbach RS, et al. CP-135,807, a selective 5-HT1D agonist: effects in drug discrimination and punishment procedures in the pigeon. Psychopharmacology (Berl) . 1996 Dec;128 (3) :313-9. |[2]Macor J E, et al. Use of 2, 5-Dimethylpyrrole as an Amino-Protecting Group in an Efficient Synthesis of 5-Amino-3-[ (N-methyl-pyrrolidin-2 (R) -yl) methyl] indole[J]. The Journal of Organic Chemistry, 1994, 59 (24) : 7496-7498.