Donitriptan (hydrochloride)
Product Specifications
UNSPSC Description
Donitriptan hydrochloride (F-11356) is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively[1].
Target Antigen
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/donitriptan-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC=C(N2CCN(C(COC3=CC4=C(NC=C4CCN)C=C3)=O)CC2)C=C1.[H]Cl
Molecular Weight
439.94
References & Citations
[1]Muñoz-Islas E, et al. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Br J Pharmacol. 2006 Sep;149(1):82-91.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103091/Donitriptan-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103091/
Clinical Information
No Development Reported
CAS Number
170911-68-9
Curated Selection
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