Donitriptan (hydrochloride)

Donitriptan hydrochloride (F-11356) is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively[1].

Product Specifications

CAS Number

[170911-68-9]

Product Name Alternative

F-11356

UNSPSC

12352005

Hazard Statement

H301-H312-H315-H319-H332-H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/donitriptan-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

N#CC1=CC=C(N2CCN(C(COC3=CC4=C(NC=C4CCN)C=C3)=O)CC2)C=C1.[H]Cl

Molecular Formula

C23H26ClN5O2

Molecular Weight

439.94

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Muñoz-Islas E, et al. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Br J Pharmacol. 2006 Sep;149 (1) :82-91.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT1 Receptor; mLAG-3

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