NPS ALX Compound 4a (dihydrochloride)
NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist, with an IC50 of 7.2 nM and a Ki of 0.2 nM[1].
Product Specifications
CAS Number
1781934-44-8
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nps-alx-compound-4a-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=S(N1C=CC2=C1C=C(N3CC(CCC4)N4CC3)C=C2)(C5=C6C=CC=CC6=CC=C5)=O.[H]Cl.[H]Cl
Molecular Formula
C25H27Cl2N3O2S
Molecular Weight
504.47
References & Citations
[1]Isaac M, et al. 6-Bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindolesderivatives as novel, potent, and selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2000 Aug 7;10 (15) :1719-21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT6 Receptor; MUC2
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