LY393558
Product Specifications
UNSPSC Description
LY393558 is a potent and orally active inhibitor of the 5-HT transporter and an antagonist of 5-HT1B and 5-HT1D receptors. LY393558 increase the extracellular levels of 5-HT in mice model frontal cortex. LY393558 can be used for researching depression[1].
Target Antigen
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly393558.html
Purity
99.0
Solubility
DMSO : 10 mg/mL (ultrasonic;warming)
Smiles
O=S(C1=CC=C(N(CCN2CC=C(C3=CNC4=C3C=CC(F)=C4)CC2)S(N(C(C)C)C5)(=O)=O)C5=C1)(C)=O
Molecular Weight
546.68
References & Citations
[1]Mitchell SN, et al. LY393558, a 5-hydroxytryptamine reuptake inhibitor and 5-HT(1B/1D) receptor antagonist: effects on extracellular levels of 5-hydroxytryptamine in the guinea pig and rat. Eur J Pharmacol. 2001;432(1):19-27.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103089/LY393558-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103089/LY393558-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
271780-64-4
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