LY393558

LY393558 is a potent and orally active inhibitor of the 5-HT transporter and an antagonist of 5-HT1B and 5-HT1D receptors. LY393558 increase the extracellular levels of 5-HT in mice model frontal cortex. LY393558 can be used for researching depression[1].

Product Specifications

CAS Number

[271780-64-4]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ly393558.html

Purity

99.0

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

O=S(C1=CC=C(N(CCN2CC=C(C3=CNC4=C3C=CC(F)=C4)CC2)S(N(C(C)C)C5)(=O)=O)C5=C1)(C)=O

Molecular Formula

C26H31FN4O4S2

Molecular Weight

546.68

References & Citations

[1]Mitchell SN, et al. LY393558, a 5-hydroxytryptamine reuptake inhibitor and 5-HT (1B/1D) receptor antagonist: effects on extracellular levels of 5-hydroxytryptamine in the guinea pig and rat. Eur J Pharmacol. 2001;432 (1) :19-27.