I-XW-053 (sodium)

I-XW-053 is an inhibitor of HIV-1 capsid protein that can suppress the replication of HIV-189BZ167 with an IC50 value of 164.2 μM. I-XW-053 exhibits antiviral activity and can block the interface between capsid protein (CA) N-terminal domains (NTD-NTD interface) with micromolar affinity[1].

Product Specifications

CAS Number

[1644644-89-2]

UNSPSC

12352005

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/i-xw-053-sodium.html

Solubility

10 mM in DMSO

Smiles

O=C(O[Na])C1=CC=C(C2=NC(C3=CC=CC=C3)=C(C4=CC=CC=C4)N2)C=C1

Molecular Formula

C22H15N2NaO2

Molecular Weight

362.36

References & Citations

[1]Kortagere S, et, al. Structure-activity relationships of a novel capsid targeted inhibitor of HIV-1 replication. J Chem Inf Model. 2014 Nov 24;54 (11) :3080-90.