MK-0674
MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S[1].
Product Specifications
CAS Number
[887781-62-6]
UNSPSC
12352005
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/MK-0674.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)[C@H](C1=CC=C(C2=CC=C(C=C2)[C@@H](O)C(F)F)C=C1)N[C@@H](CC(C)(F)C)C(NC3(CC3)C#N)=O
Molecular Formula
C26H27F6N3O2
Molecular Weight
527.50
References & Citations
[1]Isabel E, et al. The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. Bioorg Med Chem Lett. 2010 Feb 1;20 (3) :887-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin K
Available Sizes
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