(R) -Afatinib
(R) -Afatinib ((R) -BIBW 2992) is the Afatinib isomer. Afatinib is an orally active, potent and irreversible dual specificity inhibitor of?ErbB?family (EGFR?and?HER2), with?IC50?values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for?EGFRwt, EGFRL858R, ?EGFRL858R/T790M?and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung?cancer? (NSCLC) and gastric?cancer[1].
Product Specifications
CAS Number
439081-17-1
Product Name Alternative
(R) -BIBW 2992
UNSPSC
12352005
Target
C-Met/HGFR; EGFR; p38 MAPK
Type
Reference compound
Related Pathways
JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-afatinib.html
Solubility
10 mM in DMSO
Smiles
CN(C)C/C=C/C(NC1=CC(C(NC2=CC(Cl)=C(C=C2)F)=NC=N3)=C3C=C1O[C@@H]4CCOC4)=O
Molecular Formula
C24H25ClFN5O3
Molecular Weight
485.94
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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