Midostaurin-d5
Product Specifications
UNSPSC Description
Midostaurin-d5 is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1].
Target Antigen
Akt; c-Kit; Isotope-Labeled Compounds; PKA; PKC; Syk
Type
Isotope-Labeled Compounds
Related Pathways
Epigenetics;Others;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt;TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.0
Solubility
DMSO : 15 mg/mL (ultrasonic;warming)
Smiles
O=C(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])N(C)[C@H]2[C@@H](OC)[C@@]3(C)N(C4=C5C=CC=C4)C6=C5C7=C(C(NC7)=O)C8=C6N(C9=CC=CC=C98)[C@@](O3)([H])C2
Molecular Weight
575.67
References & Citations
[1]Fabbro D, et al. Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent. Pharmacol Ther. 1999 May-Jun;82(2-3):293-301.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Clinical Information
No Development Reported
Curated Selection
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