Midostaurin-d5

Midostaurin-d5 (PKC412-d5) is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1].

Product Specifications

Product Name Alternative

PKC412-d5; CGP 41251-d5

UNSPSC

12352005

Target

Akt; c-Kit; Isotope-Labeled Compounds; PKA; PKC; Syk

Type

Isotope-Labeled Compounds

Related Pathways

Epigenetics; Others; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

98.0

Solubility

DMSO : 15 mg/mL (ultrasonic; warming)

Smiles

O=C(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])N(C)[C@H]2[C@@H](OC)[C@@]3(C)N(C4=C5C=CC=C4)C6=C5C7=C(C(NC7)=O)C8=C6N(C9=CC=CC=C98)[C@@](O3)([H])C2

Molecular Formula

C35H25D5N4O4

Molecular Weight

575.67

References & Citations

[1]Fabbro D, et al. Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent. Pharmacol Ther. 1999 May-Jun;82 (2-3) :293-301.