BRD4884

BRD4884 is a potent and brain-penetrant HDAC inhibitor with IC50 values of 29 nM, 62 nM, and 1090 nM for HDAC1, HDAC2, and HDAC3, respectively. BRD4884 can be used for the study of cognitive impairment[1].

Product Specifications

CAS Number

1404559-91-6

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/brd4884.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C(C1CCOCC1)NC2=CC(C3=CC=C(F)C=C3)=CC=C2N

Molecular Formula

C18H19FN2O2

Molecular Weight

314.35

References & Citations

[1]Wagner FF, et al. Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers. Chem Sci. 2015 Jan 1;6 (1) :804-815.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC1; HDAC2; HDAC3

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