SAMT-247

SAMT-247 is a microbicide that selectively inactivate the viral nucleocapsid protein NCp7, causing zinc ejection and preventing RNA encapsidation. SAMT-247 shows good antiviral activity[1][2].

Product Specifications

CAS Number

[850715-59-2]

UNSPSC

12352005

Hazard Statement

H302

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/samt-247.html

Solubility

10 mM in DMSO

Smiles

CC(SC1=CC=CC=C1C(NCCC(N)=O)=O)=O

Molecular Formula

C12H14N2O3S

Molecular Weight

266.32

Precautions

H302

References & Citations

[1]Helmold Hait S, et al. An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes. J Immunol. 2020 Jun 15;204 (12) :3315-3328.|[2]Miller Jenkins LM, et al. Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer. Nat Chem Biol. 2010 Dec;6 (12) :887-9.|[3]Cheng-Mayer C, et al. Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide. AIDS. 2011 Sep 24;25 (15) :1833-41.