TG53
TG53 is a potent inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction. TG53 inhibits formation of a complex with integrin β1 and activation of FAK and c-Src during SKOV3 cell attachment onto FN. TG53 can be used for ovarian cancer research[1].
Product Specifications
CAS Number
946369-04-6
UNSPSC
12352005
Target
FAK; Glutaminase; Integrin; Src
Type
Reference compound
Related Pathways
Cytoskeleton; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tg53.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(NC2=NC(C)=CC(N(C)C)=N2)C=C1)C3=CC(Cl)=CC=C3OC
Molecular Formula
C21H22ClN5O2
Molecular Weight
411.88
References & Citations
[1]Gary E. Schiltz, et al. Inhibitors of tissue transglutaminase 2 (tg2) and uses thereof. Patent, US20210276960A1. 09/09/2021.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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