XIAP/cIAP1 antagonist-1

XIAP/cIAP1 antagonist-1 is a potent and orally active XIAP/cIAP1 antagonist with EC50s of 5.1 nM and 0.32 nM for XIAP and cIAP1, respectively. XIAP/cIAP1 antagonist-1 inhibits the tumor growth in dose-dependent manner in vivo[1].

Product Specifications

CAS Number

[1403898-55-4]

UNSPSC

12352005

Target

IAP

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xiap-ciap1-antagonist-1.html

Solubility

10 mM in DMSO

Smiles

C[C@H]1N(C[C@@H]2N(CC(N3CC(C)(C)C4=NC=C(CC5=CC=C(F)C=C5)C=C43)=O)C[C@@H](C)NC2)CCOC1

Molecular Formula

C29H40FN5O2

Molecular Weight

509.66

References & Citations

[1]Tamanini E, et al. Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP) . J Med Chem. 2017; 60 (11) :4611-4625.